Discussion: Why do women on average have an increased tendency compared to men to develop gallstones?

It is important to emphasize that the liver and kidneys are related. Because women of reproductive age have better protection for their liver (thanks to the female sex hormone estrogen), it also protects their kidneys better.

Fluctuations in female sex hormone levels are a significant factor, along with an unhealthy diet contributing to the formation of gallstones. The leading causes of hormonal fluctuations are births, birth control pills, and a woman's menopause.