Discussion: Women have an increased tendency (compared to men) to develop gallstones.

The leading causes of fluctuations in sex hormones in women are pregnancies, birth control pills, fertility treatments, and menopause.

The female hormone Estrogen increases women's ability to regenerate damaged internal cells and protect their liver. The estrogen level decreases with the liver's protection at the end of the woman's fertility period. After fertility, women may have an increased tendency to create Liver and Gallbladder stones. (Also during pregnancies.) The Estrogen effect on the regeneration of damaged cells is probably evolutionary since the woman has to give birth and care for the children. Male Testosterone hormone gives men better muscle-building abilities. However, in the modern age, it is not required for survival.