Discussion: Peto's paradox - Suggested comprehensive research. (Regarding cancer in mammals)

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Peto's paradox - Suggested comprehensive research. (Regarding cancer in mammals)

Peto's paradox is an observation that the incidence of cancer does not appear to correlate with the number of cells in an organism at the species level. (Wikipedia)

To date, there has been no conclusive and unequivocal finding. Peto's paradox illustrates the high complexity of cancer, which combines several dynamic factors, including heredity, environment, metabolism, living conditions, nutrition, and more. (Studying the mental-energetic dimension in animals is very complex.)

• Long-term human studies have indicated a significant statistical relationship between height and cancer incidence. (You should be careful about concluding.)
• Studies on different mammals have shown a lack of statistical association between size, weight, and cancer incidence.
• Cancer is almost non-existent in whales; dolphins (sharks—not mammals) suffer from it. Elephants, cows, horses, bats, and species of rats have virtually no cancer. Cancer is prevalent in dogs and cats.
• Over the years, researchers have proposed many explanations, including heredity, evolution, metabolic load, nutrition, etc. To date, there has been no conclusive and unequivocal finding.
Because conducting comprehensive human studies is very complex and costly, the conclusions of an extensive survey of mammals may have far-reaching implications.
• The big drug companies do not fund theoretical studies in cancer, as they have no option but to translate these studies into drugs. Without funding, it isn't easy to conduct continuous scientific research.
The starting point is that a comprehensive study of mammals will allow for drawing statistically significant unambiguous conclusions for humans.

What is required of a comprehensive study on mammalian cancer research?
• Extensive research on mammalian cancer must include a wide range of terrestrial and marine mammals, carnivores and vegetarians, and mammals of various sizes with diverse life expectancies. Compared to zoo pets and animals, males and females live freely (in nature reserves). Nutrition and environmental pollution have great significance.

Such comprehensive research must be conducted globally, especially in nature reserves, zoos, and samples of veterinary clinics in different places.
• The cost of such a study is estimated at tens of millions of dollars, but the findings may serve humanity and reveal some of the secrets of cancer.
What should the results of such a comprehensive study look like?
• Since no single factor predicts cancer, the result will be different factors that affect cancer and their statistical weight in the probability of developing various types of cancer.
Donors and research funds are the likely funding sources for such comprehensive research.
• This research cost is a modest investment, considering the vast amounts pharmaceutical companies invest in developing new drugs for cancer.

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